Publications

25. Bann, S. J., Ballantine, R. D., McCallion, C. E., Qian, P. Y., Li, Y., & Cochrane, S. A. (2019). A Chemical-Intervention Strategy to Circumvent Peptide Hydrolysis by D-Stereoselective Peptidases. Journal of medicinal chemistry​.​

Publications before joining HKU:

24. ​Zhang, W., Watanabe, H. K., Ding, W., Lan, Y., Tian, R. M., Sun, J., Chen, C. Li, Y.X., ... & Toyofuku, T. Gut microbial divergence between two populations of the hadal amphipod Hirondellea gigas. Appl. Environ. Microbiol., 2019, 85(1), e02032-18.

23. ​Zhang, W., Ding, W., ​Li, Y. X., Tam, C., Bougouffa, S., Wang, R., ... & Sun, J. Marine biofilms constitute a bank of hidden microbial diversity and functional potential. Nature communications, 2019, 10(1), 517.

22. Li YX#, Zhong Z#, Zhang W, Qian PY. Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining. Nature Communication, 2018,9(1): 3273.  (Editor’s Highlights paper in Therapeutics， Recommended by F1000 Prime as ‘the first discovery of an antibiotic from a genomics approach that shows efficacy in treating a systemic infection’).

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21. ​Ballantine, R.D., ​Li, Y.X., Qian, P.Y. and Cochrane, S.A. Rational design of new cyclic analogues of the antimicrobial lipopeptide tridecaptin A 1. Chemical Communications, 2018, 54(75), pp.10634-10637.

20. ​Li YX, Zhong Z, Hou P, Zhang W, Qian PY. Resistance to nonribosomal peptide antibiotics mediated by D-stereospecific peptidases. Nature Chemical Biology, 2018, 14(4), 381-385. (Highlighted by: F1000 Prime, Xinhua News, TVB News, BTV News, AsiaScientist, Science Daily, Science Newsline, EurekAlert, and more than ten local Newspapers of Hong Kong).

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19. ​Zhang W, Tian RM, Sun J, Bougouffa S, Ding W, Cai L, Lan Y. Tong H, Li YX, Jamieson AJ and Bajic VB, Drazen JC, Bartlett D, Qian PY . Genome Reduction in Psychromonas Species within the Gut of an Amphipod from the Ocean’s Deepest Point. MSystems, 2018 3: e00009-18.

18. ​Li Z, Li J, Gu JP, Lai JYH, Duggan BM, Zhang WP, Li ZL, LiYX, RB Tong, Moore B, & Qian PY, Discovery of precolibactin-886, the missing aminomalonate-containing member of the genotoxin colibactin family. Nature Chemical Biology, 2016 12(10): 773–775.

17. ​Li ZR, Li YX, Lai JYH, Tang J, Wang B, Lu L, Zhu G, Wu X, Xu Y, Qian PY. Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway. ChemBioChem, 2015, 16(12), 1715-1719.

16. ​Li YX, Li Z, Yamanaka K, Xu Y, Zhang W, Vlamakis H, Kolter R, Moore BS, Qian PY. Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis. Scientific reports, 2015, 5:9383.

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15. ​Qian PY, Li Z, Xu Y, Li YX, Fusetani N. Mini-review: Marine natural products and their synthetic analogs as antifouling compounds: 2009–2014. Biofouling, 2015, 31(1), 101-122.

14. ​Zhang W, Wang Y, Bougouffa S, Tian R, Cao H, Li YX, Cai L, Wong YH, ... & Qian PY. Synchronized dynamics of bacterial niche‐specific functions during biofilm development in a cold seep brine pool. Environmental microbiology, 2015, 17, 4089–4104.

13. ​Wang KL, Xu Y, Lu L, Li YX, Han Z, Zhang J, ... & Qian PY. Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds. Marine Biotechnology, 2015, 17(5), 624-632.

12. ​Lu L, Wang J, Xu Y, Wang K, HuY., Tian R, Li YX, ... & PY., Qian. A High-Resolution LC-MS-Based Secondary Metabolite Fingerprint Database of Marine Bacteria. Scientific reports, 2014, 4, 6537.

11. ​Zhang W, Wang Y, Lee OO, Tian R, Cao H, Gao Z, Li YX, L Yu, Y Xu, Pei-Yuan QianAdaptation of intertidal biofilm communities is driven by metal ion and oxidative stresses, Scientific reports, 2013, 3, 3180.

10. ​Liu LL, He LS, Xu Y, Han Z, Li YX, Zhong JL, Guo XR, Zhang XX, Ko KM, Qian PY.  Caspase-3-Dependent Apoptosis of Citreamicin ε-Induced HeLa Cells Is Associated with Reactive Oxygen Species Generation, Chem. Res. Toxicol., 2013, 26(7), 1055–1063.

9. ​Li YX#, Wu HX#, Xu Y, Shao CL, Wang CY, Qian PY. Antifouling activity of secondary metabolites isolated from Chinese marine organisms. Marine Biotechnology, 2013, 15(5):552-558. 

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8. ​Li YX, Xu Y, Liu L, Han Z, Lai PY, Guo X, Zhang X, Lin W, Qian PY. Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis. Marine drugs, 2012, 10(2):319-28.7.

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7. ​Li YX, Zhang F, Xu Y, Matsumura K, Han Z, Liu L, Lin W, Jia Y, Qian PY. Structural optimization and evaluation of butenolides as potent antifouling agents: modification of the side chain affects the biological activities of compounds. Biofouling, 2012, 28(8):857-64. 

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6. ​Li YX, Yu S, Liu D, Proksch P, Lin W. Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L. Bioorganic & medicinal chemistry letters, 2012, 22(2):1099-102.

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5. ​Han Z, Xu Y, McConnell O, Liu LL, Li YX, Qian PY. Two antimycin A analogues from marine-derived Actinomycete Streptomyces lusitanus, Marine drugs, 2012, 10, 668-676.

4. ​Liu LL, Xu Y, Han Z, Li YX, Lu L, Lai PY, Zhong JL, Guo XR, Zhang XX, Qian PY. Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs, 2012, 10, 2571-2583.

3. ​Lai DW, Li YX, Xu Mj, Deng ZW, Ofwegen LV, Qian PY, WH Lin. Sinulariols A–S, 19-oxygenated cembranoids from the Chinese soft coral Sinularia rigida, Tetrahedron, 2011, 67, 6018-6029.

2. ​Li YX, Liu J, Yu S, Proksch P, Gu J, Lin W. TNF-α inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L. Phytochemistry, 2010, 71:2124-31.

1. ​LI YX, Yu X, Yu SJ, Lin WH. Phenolic glucopyranosides from the Chinese mangrove plant Excoecaria agallocha, J. Chin. Pharm. Sci., 2010, 19, 256-259.